ANALYSIS OF HEAT-SHOCK-PROTEIN-60 EPITOPES IN TRANSGENIC MICE

Transgenic non obese diabetic mice (NOD) have been generated that expr ess murine heat shock protein 60 (Hsp60) on an H-2E alpha promoter. Th ese mice have been shown to be protected from diabetes, but to suffer from exacerbated sialitis and experimental autoimmune encephalomyeliti s (EAE). Protection from diabetes is not the result of negative select ion of all Hsp60 reactive T cell clones; responses to self Hsp60 are o bserved despite high expression in the thymus [1].