Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission

Citation
Sf. Lockett et al., Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission, J INFEC DIS, 180(3), 1999, pp. 614-620
Citations number
39
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
180
Issue
3
Year of publication
1999
Pages
614 - 620
Database
ISI
SICI code
0022-1899(199909)180:3<614:EOCRMO>2.0.ZU;2-Y
Abstract
To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexu al human immunodeficiency virus (HIV) transmission, 144 persons heterosexua lly exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped, A significantly higher frequency of 64I heterozyg otes at CCR-2 was observed in HIV-positive than in EU women (P = .02, relat ive risk = 1.6). The allele frequency of 64I in women was 8% in HIV-positiv e contacts and 1% in EUs (P <.02), At CCR-5, no difference in the frequency of Delta 32 was seen between groups, and the CCR-5 genotypes did not diffe r in accumulated "at-risk" exposure in EUs, Combining the analysis of the D elta 32 and 64I mutations in index partners suggested an additive effect on transmission (P =.10). Thus heterozygosity for 64I at CCR-2 acts as a risk factor for HIV infection of women after heterosexual contact but heterozyg osity for Delta 32 at CCR-5 has no detectable effect.