Novel arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides as platelet aggregation inhibitors. 2. Optimization by quantitative structure-activity relationships

In the previous paper (Part 1), we described the synthesis and antiplatelet activity of a series of phenyl- and heteroarylpyrazino[2,3-c][1,2,6]thiadi azine 2,2-dioxides. In this paper, we report the optimization of the platel et aggregation inhibitory activity by an iterative sequence of quantitative structure-activity relationship studies which encompassed synthesis and ev aluation of the effects of structure variations at the 1-, 6-, and 7-positi ons of the heterocyclic system. A model has been established that correctly correlates antiplatelet activity in this series with the partial atomic ch arges calculated by a local density functional ab initio method. As a resul t of this study, the experimental platelet aggregation inhibitory activity of the lead compound was improved 300-fold.