Eosinophilic dermatitis with edema in nine dogs, compared with eosinophilic cellulitis in humans

A unique eosinophilic dermatitis with edema in dogs is characterized by ext remely erythematous coalescing macules and plaques with associated edema, a nd is similar to eosinophilic cellulitis (Wells' syndrome) in humans.) Histopathologic features include a profound eosinophilic dermal infiltrate, focal areas of collagen fiber degeneration surrounded by eosinophils (flam e figures), dilated vessels, and dermal edema.) Etiopathogenesis is unknown, but a hypersensitivity reaction to medications , arthropod bites, or other foreign antigens is suspected.