Background: Management of cibenzoline succinate (cifenline) poisoning by sy
mptomatic treatment is recommended because it has been reported cibenzoline
succinate is not effectively removed by hemodialysis.(1) The use of charco
al hemoperfusion for patients with cibenzoline succinate poisoning has not
been reported previously. Case Report: An 80-year-old woman with permanent
right ventricular pacing was admitted to our hospital with general fatigue
and clouding of consciousness. She had been receiving cibenzoline succinate
for 1 month. The patient was clearly in shock on admission. Electrocardiog
ram showed a prolonged QRS and QTc interval and pacing failure. Hemodynamic
failure, electrocardiographic abnormalities including pacing failure, and
liver and renal dysfunction were compatible with cibenzoline succinate pois
oning, Symptomatic treatment was provided. On day 4, charcoal hemoperfusion
was initiated because of the development of hypoglycemia accompanied by li
ver and renal dysfunction. After charcoal hemoperfusion, the hypoglycemia,
liver and renal dysfunction, prolonged QRS and QTc interval, and pacing thr
eshold resolved. She was discharged on digoxin, We present a case of cibenz
oline succinate poisoning treated with charcoal hemoperfusion which resulte
d in a rapid reduction of cibenzoline plasma concentrations with a signific
ant clinical improvement.