Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy

Authors
Vaidya, B Imrie, H Perros, P Dickinson, J McCarthy, MI Kendall-Taylor, P Pearce, SHS
Citation
B. Vaidya et al., Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy, LANCET, 354(9180), 1999, pp. 743-744
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
354
Issue
9180
Year of publication
1999
Pages
743 - 744
Database
ISI
SICI code
0140-6736(19990828)354:9180<743:CTLA(G>2.0.ZU;2-C
Abstract
Smoking and demographic variables are known to be risk factors for the deve lopment of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established . We show that the presence and severity of TAO are associated with an alle le of the cytotoxic T lymphocyte antigen-4-gene.