Regulation of prostaglandin production by inhibition of poly (ADP-ribose) synthase in carrageenan-induced pleurisy

The aim of the present study was to investigate the effect of two inhibitor s (3-aminobenzamide and nicotinamide) of poly (ADP-ribose) synthetase on th e production of the inflammatory mediator prostaglandins in a model of acut e inflammation, carrageenan-induced pleurisy, where prostaglandins are know n to play a crucial role. The results show that the poly (ADP-ribose) synth etase inhibitors, 3-aminobenzamide (2.5, 5 and 10 mg/kg) and nicotinamide ( 12.5, 25 and 50 mg/kg), inhibit the inflammatory response (pleural exudate formation, polymorphonuclear cell infiltration and prostaglandin production ). The present results demonstrate that inhibition of poly (ADP-ribose) syn thetase exerts potent anti-inflammatory effects. Part of these anti-inflamm atory effects may be related to a reduction of prostaglandin production dur ing the inflammatory process.