The algorithm for cross-evaluation (ACE) of biologically active compounds

A non-linear algorithm, ACE (Algorithm for Cross-Evaluation), was developed to correlate the activity of anti-cancer drugs against human cell lines. A CE evaluates the relationships among compounds and cell lines and displays the resulting clusters on a 3-D surface plot. This plot along with a freque ncy plot and rank graph provides clear information regarding the sensitivit y of groups of cell lines to particular compounds. The program was tested o n published anti-cancer data sets and found associations useful in the sele ction and design of chemotherapy drugs for pre-clinical trials, ACE may be applied to other situations where details of groupings and relationships ne ed to be extracted from large sets of data.