Ch. Kao et al., Cytokeratin fragment 19 (CYFRA 21-1) and carcinoembryonic antigen for early prediction of recurrence of lung adenocarcinoma, LUNG, 177(5), 1999, pp. 333-337
Fifty patients with adenocarcinoma of the lung were enrolled in this study,
including 20 patients with recurrence and 30 patients without recurrence 1
year after surgery. Serial serum levels of cytokeratin fragment 19 (CYFRA
21-1) and carcinoembryonic antigen (CEA) were measured before the operation
and 1 week, 1 month, 3 months, 6 months, 9 months, and 12 months after sur
gery for the early detection of recurrence. The results revealed that the m
ean serum values of either CYFRA 21-1 or CEA were significantly higher unti
l 9 and 12 months after surgery in the 20 patients with recurrent adenocarc
inoma compared with the 30 patients without recurrent adenocarcinoma. We co
nclude that CYFRA 21-1 is not a better marker than CEA for early prediction
of adenocarcinoma. We conclude that CYFRA 21-1 is not a better marker than
CEA for early prediction of adenocarcinoma recurrence in lung.