Investigations on magnesium and chromium antagonism in the skin of experimental animals

Investigations were performed over 30 days on 25 male rats Wistar breed div ided into five groups. Animals received intraperitoneally tip) potassium di chromate (KDCH) 5 mg/kg (basal doses, b.d.), 2 mg/kg (0.4 b.d.) and 100 mg Mg Cl-2/kg body weight (b.w.). In performed investigations the highest conc entration of chromium in animal skin 1.17 +/- 0.11 mu g/g was observed by i p administration of KDCH 5 mg /kg b.w. Simultaneous ip administration of KD CH 5 mg/kg B.W. and MgCl2 100 mg/kg b.w, resulted in significant lower conc entration of chromium tin comparison to the preceding group) in animal skin : 0.8 +/- 0.2 mu g/g (p<0.001). In ip administration of KDCH in the doses o f 0.4 b.d, the concentration of Cr in the skin amounted to 0.55 +/- 0.1 mu g/g. Values of Cr in the skin in exposed groups were significantly higher t han in the control group. (p<0.001).