THE EFFECT OF MODIFIED FORMS OF VASOPRESS IN ON HOMEOSTASIS IN RATS

The effect of modified forms of vasopressin (MFV) that do not posses h ormonal activity on homeostasis in rats was studied. One of the major effects of vasopressin (AVP) and its analogs on the bloodclotting syst em, changes in fibrinolytic activity (FA) and the activity of plasmino gen activator (APA), depends on modifications of the amino acid sequen ce in the peptide molecule. The presence of glycinamide in the AVP mol ecule enhances FA and APA. AVP molecules without the glycinamide group exert a more marked influence on procoagulative activity in blood.