Proconvulsive effect of tea (Camellia sinensis) in mice

Investigations were carried out to evaluate the effect of acute and chronic administration of both black and green tea on three models of experimental ly induced convulsions in mice. Tea extract (both black and green) signific antly accelerated the onset of convulsion, increased the duration of convul sion and mortality in mice. Since both the extracts failed to alter the GAB A level in brain, based on the earlier report that both black and green tea might act on Ca2+ channels, it can be suggested that the observed proconvu lsive effect of tea not mediated through GABA but through Ca2+ channels. Co pyright (C) 1999 John Wiley & Sons, Ltd.