U. Rigney et al., The effects of acute doses of standardized Ginkgo biloba extract on memoryand psychomotor performance in volunteers, PHYTOTHER R, 13(5), 1999, pp. 408-415
This study investigated the effects of acute doses of Ginkgo biloba extract
(GBE) on memory and psychomotor performance in a randomized, double-blind
and placebo controlled 5-way cross-over design. Thirty-one volunteers aged
30-59 years received GEE 150 mg (50 mg t.d.s), GEE 300 mg (100 mg t.d.s.),
GEE 120 mg mane and GEE WO mg mane and placebo for 2 days. Following baseli
ne measures, the medication was administered at 0900 h for the single doses
and at 0900, 1500 and 2100 h for the multiple doses. The psychometric test
battery was administered pre-dose (0830 h) and then at frequent intervals
until 11h post dose.
The results confirm that the effects of GEE extract on aspects of cognition
in asymptomatic volunteers are more pronounced for memory, particularly wo
rking memory. They also show that these effects may be dose dependent thoug
h not in a linear dose related manner, and that GEE 120 mg produces the mos
t evident effects of the doses examined. Additionally, the results suggest
that the cognitive enhancing effects of GEE are more likely to be apparent
in individuals aged 50-59 years. Copyright (C) 1999 John Wiley & Sons, Ltd.