Novel experimental model using free radical-induced emesis for surveying anti-emetic compounds from natural sources

Authors
Yang, Y Kinoshita, K Koyama, K Takahashi, K Tai, T Nunoura, Y Watanabe, K
Citation
Y. Yang et al., Novel experimental model using free radical-induced emesis for surveying anti-emetic compounds from natural sources, PLANTA MED, 65(6), 1999, pp. 574-576
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
6
Year of publication
1999
Pages
574 - 576
Database
ISI
SICI code
0032-0943(199908)65:6<574:NEMUFR>2.0.ZU;2-J
Abstract
A novel experimental model of free radical-induced emesis for screening ant i-emetic compounds from natural sources was established. 2,2'-Azobis(2-amid inopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2 -mercaptopropionyl)-glycine (MPG), alpha-tocopherol, and L-ascorbic acid. T ropiseton, a serotonin receptor antagonist. also prevented emesis induced b y AAPH. Known anti-emetic drugs and anti-emetic principles from natural sou rces also showed significant retching inhibition in the experiment using th is system.