The relationship of nonsteroidal anti-inflammatory drug use to the risk ofbreast cancer

Citation
Pf. Coogan et al., The relationship of nonsteroidal anti-inflammatory drug use to the risk ofbreast cancer, PREV MED, 29(2), 1999, pp. 72-76
Citations number
15
Categorie Soggetti
General & Internal Medicine
Journal title
PREVENTIVE MEDICINE
ISSN journal
00917435 → ACNP
Volume
29
Issue
2
Year of publication
1999
Pages
72 - 76
Database
ISI
SICI code
0091-7435(199908)29:2<72:TRONAD>2.0.ZU;2-2
Abstract
Background. The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of breast cancer is unclear. We assessed the association in a hosp ital-based case-control study. Methods. The cases (n = 6558) were compared with cancer controls (n = 3296) and noncancer controls admitted for trauma or acute infection (n = 2925). Odds ratios were estimated using multivariate logistic regression models. Results. For women who used NSAIDs regularly beginning at least 1 year befo re admission, the odds ratios (OR) were 0.8 (95% CI 0.7, 1.0) with cancer c ontrols and 0.7 (95% CI 0.6, 0.9) with noncancer controls. With noncancer c ontrols, there was a statistically significant decreasing trend in the odds ratios as duration of use increased, whereas with cancer controls there wa s not. The reduction in risk for regular use was accounted for largely by a reduced odds ratio for one study center (Boston), which contributed 9% of the cases. Conclusions. The data are compatible with a small reduction in risk, associ ated with regular NSAID use. However, inconsistencies in the data detract f rom a causal interpretation. (C) 1999 American Health Foundation and Academ ic Press.