Liposclerosing myxofibrous tumor: A radiologic-pathologic-distinct fibro-osseous lesion of bone with a marked predilection for the intertrochanteric region of the femur

PURPOSE: To describe the characteristic features of liposclerosing myxofibr ous tumor (LSMFT) of bone. MATERIALS AND METHODS: The radiographs and clinical histories of 39 patient s (21 male, 18 female; mean age, 42 years; age range, 15-69 years) with his tologically verified LSMFT of bone were retrospectively studied. RESULTS: LSMFT had a predilection for the proximal femur; more than 90% (30 of 33) of the femoral lesions were in the intertrochanteric region. Radiog raphs showed an indolent growth pattern with a well-defined and often exten sively sclerotic margin. The bone contour either was normal or showed mild expansile remodeling. Mineralization within the lesion was not uncommon. Sc intigrams showed mild to moderate focal tracer accumulation. Findings at co mputed tomography reflected those at radiography, whereas magnetic resonanc e imaging findings were nonspecific. Four (10%) patients had evidence of ma lignant transformation. CONCLUSION: The radiologic appearance of LSMFT in the intertrochanteric reg ion of the femur is characteristic. The substantial prevalence of malignant transformation associated with LSMFT underscores the need for close observ ation of this lesion.