Purines, pyrimidines, and fused systems based on them 16. Oxidative amination of 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione

Authors
Gulevskaya, AV Besedin, DV Pozharskii, AF
Citation
Av. Gulevskaya et al., Purines, pyrimidines, and fused systems based on them 16. Oxidative amination of 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione, RUSS CHEM B, 48(6), 1999, pp. 1150-1153
Citations number
8
Categorie Soggetti
Chemistry
Journal title
RUSSIAN CHEMICAL BULLETIN
ISSN journal
10665285 → ACNP
Volume
48
Issue
6
Year of publication
1999
Pages
1150 - 1153
Database
ISI
SICI code
1066-5285(199906)48:6<1150:PPAFSB>2.0.ZU;2-0
Abstract
6,8-Dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione reacts with ammonia or primary amines in the presence of an oxidant to give the corresponding 4 -amino derivatives. Reactions with secondary amines (dimethylamine, piperid ine, or morpholine) proceed with difficulty, resulting in 3-amino derivativ es.