The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues.

Authors
Coxon, GD Knobl, S Roberts, E Baird, MS Al Dulayymi, JR Besra, GS Brennan, PJ Minnikin, DE
Citation
Gd. Coxon et al., The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues., TETRAHEDR L, 40(36), 1999, pp. 6689-6692
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
36
Year of publication
1999
Pages
6689 - 6692
Database
ISI
SICI code
0040-4039(19990903)40:36<6689:TSOBEO>2.0.ZU;2-R
Abstract
(11R, 12S)-lactobacillic acid (1) has been prepared either from D-mannitol by asymmetric cyclopropanation or from cycyclopropane-1, 2-dimethanol by en zymatic desymmetrisation. The syntheses of (11S, 12R)-lactobacillic acid (2 ) and (1R, 2S) 1(3'-methoxycarbonylpropyl)-2-octadecylcopropane (26) and re lated analogues (27 and 28) have also been achieved. (C) 1999 Elsevier Scie nce Ltd. All rights reserved.