Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates

Authors
Reese, CB Visintin, C
Citation
Cb. Reese et C. Visintin, Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates, TETRAHEDR L, 40(35), 1999, pp. 6477-6480
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
35
Year of publication
1999
Pages
6477 - 6480
Database
ISI
SICI code
0040-4039(19990827)40:35<6477:DOPDAO>2.0.ZU;2-E
Abstract
The conversion of four 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyribonucleoside 3 '-H-phosphonates 1 (B=4, 5, 6 and 7) into their partially-protected nucleos ide precursors 3 (B=4, 5, 6 and 7, respectively) in good isolated yields is described. The procedure used is also suitable for the dephosphonylation o f protected oligonucleotide H-phosphonate blocks. (C) 1999 Elsevier Science Ltd. All rights reserved.