Brownian dynamics simulations of the beta(2)-adrenergic receptor extracellular loops: evidence for helix movement in ligand binding?

Brownian dynamics simulations of the gating mechanism of the extracellular loops of the beta(2)-adrenergic receptor suggest that loop gating alone wil l not permit the larger ligands to bind and hence suggests that lateral hel ix movement is also required in the binding process. (C) 1999 Elsevier Scie nce B.V. All rights reserved.