A toxic extract from sea urchin (T-pileolus) inhibits Ca-45(2+) uptake in P-2 fraction from chick brain under physiological ionic conditions

Authors
Zhang, YA Wada, T Nakagawa, H Ichida, S
Citation
Ya. Zhang et al., A toxic extract from sea urchin (T-pileolus) inhibits Ca-45(2+) uptake in P-2 fraction from chick brain under physiological ionic conditions, TOXICON, 37(11), 1999, pp. 1639-1643
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICON
ISSN journal
00410101 → ACNP
Volume
37
Issue
11
Year of publication
1999
Pages
1639 - 1643
Database
ISI
SICI code
0041-0101(199911)37:11<1639:ATEFSU>2.0.ZU;2-Z
Abstract
An acidic toxic extract from the sea urchin T. pileolus inhibited time-depe ndent Ca-45(2+) uptake in chick P-2 fraction (IC50 about 10 ng/ml). This to xic extract is susceptible to trypsin. The inhibitory effect probably relat e to Na+/Ca2+ exchanger. (C) 1999 Elsevier Science Ltd. All rights reserved .