SYNTHESIS AND CYTOSTATIC PROPERTIES OF 5-SUBSTITUTED DERIVATIVES OF 3-METHYLISOXAZOLO[5,4-D]1,2,3-TRIAZINE-4-ONES AND 3-METHYL-5-TRIAZENE-4-ISOXAZOLOCARBOXYLIC ACID ETHYL-ESTERS

Six new 5-substituted derivatives of 3-methyl-isoxazolo[5,4-d]1,2,3-tr iazine- and 3-methyl-5-triazene-4-isoxazolecarboxylic acid ethyl ester have been synthesized from 5-amino-3-methylisoxazole-4-carboxylic aci d amides, and ethyl ester. They were examined for cytostatic activity in comparison with Dacarbazine. The -chlorophenyl)isoxazolo[5,4-d]1,2, 3-triazine-4-one showed better activity than Dacarbazine.