A QSAR STUDY CONFIRMING THE HETEROGENEITY OF THE HEPT DERIVATIVE SERIES REGARDING THEIR INTERACTION WITH HIV REVERSE-TRANSCRIPTASE

Authors
TRONCHET JMJ GRIGOROV M DOLATSHAHI N MORIAUD F WEBER J
Citation
Jmj. Tronchet et al., A QSAR STUDY CONFIRMING THE HETEROGENEITY OF THE HEPT DERIVATIVE SERIES REGARDING THEIR INTERACTION WITH HIV REVERSE-TRANSCRIPTASE, European journal of medicinal chemistry, 32(4), 1997, pp. 279-299
Citations number
20
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
32
Issue
4
Year of publication
1997
Pages
279 - 299
Database
ISI
SICI code
0223-5234(1997)32:4<279:AQSCTH>2.0.ZU;2-E
Abstract
QSAR concerning the anti-HIV and cytotoxic activities of a series of H EPT analogues has been established using a Hansch-type approach (TSAR( TM)), a neural network approach (TSAR) and a pharmacophore search meth od (CATALYST(TM)). The techniques employed allowed reliable activity p redictions and confirmed the heterogeneity of this series of compounds , which was previously established in biochemical experiments.