Chemotherapy of CNS - Trypanosomiasis: The combined use of isometamidium and difluoromethylornithine (DFMO) in immunosuppressed rabbits

Authors
Onyeyili, PA Egwu, GO Oliyu, MM Bukar, AU
Citation
Pa. Onyeyili et al., Chemotherapy of CNS - Trypanosomiasis: The combined use of isometamidium and difluoromethylornithine (DFMO) in immunosuppressed rabbits, ACT VET BEO, 49(2-3), 1999, pp. 163-169
Citations number
19
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
ACTA VETERINARIA-BEOGRAD
ISSN journal
05678315 → ACNP
Volume
49
Issue
2-3
Year of publication
1999
Pages
163 - 169
Database
ISI
SICI code
0567-8315(1999)49:2-3<163:COC-TT>2.0.ZU;2-3
Abstract
The therapeutic efficacy of difluoromethylornithine (DFMO) and isometamidiu m chloride combinations were investigated in immunosuppressed rabbits infec ted with Trypanosoma brucei brucei. Treatments with DFMO in drinking water plus isometamidium intramuscularly were observed to be ineffective, even in combinations which were 100 percent effective in immunocompetent animals. It is therefore suggessted that a competent immune system is important in t he chemotherapy of T. b. brucei using DFMO/ isometamidium combinations.