CHEMICAL-STRUCTURE OF LIPID-A FROM HELICOBACTER-PYLORI STRAIN-206-1 LIPOPOLYSACCHARIDE

The chemical structure of a novel lipid A, which was obtained as a maj or component from lipopolysaccharide of Hebicobacter pylori strain 206 -1, was determined to be a glucosamine beta(1-6) disaccharide 1-(2-ami noethyl)phosphate acylated by (R)-3-hydroxyoctadecanoic acid and (R)-3 -(octadecanoyloxy)octadecanoic acid at the 2- and 2'-position, respect ively, The absence of a phosphoryl group at the 4'-position and fatty acyl groups at the 3- and 3'-position, and the stoichiometric presence of 2-aminoethyl phosphate at the 1-position are unique features, dist inguishing it from the lipid A of enterobacteria.