K. Gloeckner et al., Colonic primary large cell lymphoma with marginal zone growth pattern presenting as multiple polyps, AM J SURG P, 23(9), 1999, pp. 1149-1153
Citations number
11
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
We report a rare case of primary gastrointestinal lymphoma, stage IE, in a
58-year-old white man who had multiple colonic polyps measuring up to 1 x 1
.1 cm. The tumor originated in the marginal zone of the follicles infiltrat
ing the interfollicular spaces. Follicular colonization was frequently seen
. The mucosa was spared by the infiltrate. Morphologically, the neoplastic
cells were monomorph, intermediate-sized blasts. Rare small to intermediate
sized cells, some with centrocyte-like morphology, intermingled the blasti
c infiltrate. The neoplastic cells expressed CD20 and had a monotypic immun
oglobulin of cytoplasmic IgM (kappa) on paraffin sections. Tumor cells stai
ned negative for CD45RO, CD5, CD10, IgD, and CD23. Polymerase chain reactio
n revealed a clonal V-D-J rearrangement. Bcl-1 and bcl-2 rearrangement were
not detected. We therefore suggest the diagnosis of primary large cell lym
phoma with marginal zone growth pattern mimicking colonic adenomas.