EXPRESSION OF ER-D5 AND EGFR IN LARYNGEAL CARCINOMA AND PREMALIGNANT EPITHELIUM

The expression of estrogen receptors was biochemically assessed in a s eries of 46 cases of consecutive laryngeal carcinomas. ER-D5 and EGFr were also immunohistochemically detected in 44 and 46 cases respective ly. There was no correlation between the expression of these molecules and the typical anatomo-clinical prognostic parameters of laryngeal t umors. The concomitant expression of estrogen receptors, ER-D5 and EGF r was also investigated in normal, hyperplastic and dysplastic epithel ium. An increasing expression of ER-D5 and EGFr from normal to hyperpl astic and dysplastic epithelium was noted. These data suggest a possib le role of hormone receptors in the laryngeal carcinogenesis.