Regional musculoskeletal disorders are a major cause of morbidity both in t
he community and in the workplace. They comprise a heterogeneous group of c
onditions that are, for the most part, poorly characterized. Consequently,
agreed diagnostic criteria have not existed for many of these disorders, an
d epidemiological investigations have used varied or ill-defined approaches
to case definition. This chapter describes our current understanding of th
e epidemiology of regional pain disorders and details the strengths and wea
knesses of the available data. Pain syndromes can be divided anatomically i
nto those which cause generalized pain, such as fibromyalgia syndrome and m
yofascial pain syndromes, and those which are confined to one regional anat
omical area. The latter group comprise those of the neck, shoulder, elbow,
wrist/hand, hip, knee and ankle/foot. Current information is considered on
the known risk factors for disorders at these sites, in addition to their i
mpact upon both the individual and society.