There is a general lack of new evidence on which to base practical and usef
ul diagnostic classifications of regional musculoskeletal pain for primary
care. However, the 'red flag' system, developed and now disseminated succes
sfully in the management of low back pain, seems to be applicable to the in
itial management of other regional pain. In this scheme, signs and symptoms
of serious disease are sought, and their presence is the indication for th
e investigation or referral of individual patients. In their absence, the l
ow predictive value of many signs, tests and even diagnostic labels argues
against their routine use in primary care. Simple decisions based on separa
tion into articular versus non-articular, and acute versus chronic, are fav
oured by the most recent expert consensus statements. In addition, the pres
ence or absence of more widespread pain, and of other non-specific features
of chronic pain, is likely to be helpful in managing regional syndromes. P
rospective studies of the prognostic value of symptoms, signs and diagnosti
c labels remain a research priority in this field.