Heterogeneicity of chloroquinoresistant malaria in Senegal.

In order to evaluate the in vivo efficacy of chloroquine in the treatment o f P. falciparum malaria, studies have been carried out in Richard-Toll, Fat ick and Tambacounda, 3 areas where dynamics of transmission, population mov ements as well as prophylactic and curative practises are different. Failur e rates in treatment were 13% in site 1 (Richard-Toll) where medical pressu re and population movements are high. In sites 2 and 3 (Fatick and Tambacou nda) the failure rate was 3%. Even ii medical pressure is lower in the latt er site (Tambacounda), the higher transmission could be a factor in the spr eading of resistance. A surveillance system and better use of chloroquine must be undertaken.