NONTOXIC EMBOLIC LIQUIDS FOR TREATMENT OF ARTERIOVENOUS-MALFORMATIONS

Interventional radiology is becoming one of the standard treatments of arteriovenous malformation (AVM), Cyanoacrylate derivatives and polym er solutions are widely used to occlude the AVM nidus by their injecti on through a catheter, but they are far from satisfactory embolic liqu ids, For instance, cyanoacrylate derivatives sometimes glue the cathet er to the artery, resulting in serious complications; in addition, the organic solvents used to dissolve polymers cause damage to the surrou nding brain tissue of the AVM, Therefore, we attempted to develop embo lic liquids by dissolving poly(2-hydroxy-ethyl methacrylate-co-methyl methacrylate) in Iopamiron with an addition of a small amount of ethyl alcohol, This new embolic liquid is not cytotoxic and is easily injec ted into the AVM through a thin, long catheter to effectively occlude the AVM. (C) 1997 John Wiley & Sons, Inc.