Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse

Germ-line mutations in APC and mismatch repair genes explain only a small p ercentage of all colorectal cancer cases. We have used the recombinant cong enic strain mouse model to find new loci that are involved in the control o f susceptibility to colon cancer. Five different colon cancer susceptibilit y genes, Scc1-Scc5, have been described previously using the recombinant co ngenic strains. Two of these loci, Scc4 and Scc5, show a reciprocal, geneti c interaction. Here we report the mapping of four new colon tumor susceptib ility genes: (a) Scc6 on chromosome 11; (b) Scc7 on chromosome 3; (c) Scc8 on chromosome 8; and (d) Scc9 on chromosome 10. Scc7 and Seed show a geneti c interaction; Scc7 is only detected by virtue of its interaction with Scc8 .