We investigate functors between abelian categories having isomorphic left a
nd right adjoint functors (these functors are called Frobenius Functors). T
hey are characterized for categories of modules and categories of comodules
. We give some applications in coalgebras and Hopf modules. In particular,
we introduce the notion of Frobenius homomorphism of coalgebras. The set of
isomorphism classes of Frobenius functors between quite general Grothendie
ck categories is endowed with an abelian group structure. This gives a func
torial notion of Grothendieck group which behaves satisfactorily.