Effects of long term administration of testosterone enanthate on glucose metabolism in rhesus monkeys

The effects of long term administration of testosterone enanthate (TE) on g lucose metabolism including glucose tolerance test (GTT) and fasting serum insulin levels were evaluated in adult rhesus monkeys kept under controlled dietary conditions. Adult male rhesus monkeys (n = 9) were administered 50 mg of TE bimonthly for 32 months, whereas control animals were injected th e vehicle only. Glucose concentration reached a maximum 5 min after an intr avenous glucose load and thereafter decreased gradually to reach near basel ine values within 60 min. Significant changes in GTT or t(1/2) of glucose w ere not seen in animals treated with TE, throughout the treatment period. H owever, serum insulin levels decreased significantly from months 27-32 of T E treatment and returned to baseline values within 3 months of recovery. CO NTRACEPTION 1999; 59:333-337 (C) 1999 Elsevier Science Inc. All rights rese rved.