J. Hennig et al., IMPROVED SENSITIVITY TO OVERLAPPING MULTIPLET SIGNALS IN IN-VIVO PROTON SPECTROSCOPY USING A MULTIECHO VOLUME SELECTIVE (CPRESS) EXPERIMENT, Magnetic resonance in medicine, 37(6), 1997, pp. 816-820
A method for volume selective proton spectroscopy is presented based o
n a multiecho sequence with short refocusing interval top. It is demon
strated, that by appropriate choice of top on the order of 4-6 ms, sig
nals from overlapping multiplets like the glutamine and glutamate (Glu
/Gln) resonances in spectra of the human brain are considerably increa
sed compared with a conventional PRESS volume selection scheme. Thus p
roton spectra from J-coupled multiplet signals can be acquired with TE
on the order of 20-30 ms avoiding the baseline problems arising at sh
orter echo times due to broad resonances. This allows to selectively a
cquire spectra from substances with longer T-2 without the confounding
effects from J-coupling occurring in conventional volume selection te
chniques.