FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF MEDIAN NERVE-STIMULATION IN RATS AT 2.0 T

Authors
SCANLEY BE KENNAN RP CANNAN S SKUDLARSKI P INNIS RB GORE JC
Citation
Be. Scanley et al., FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF MEDIAN NERVE-STIMULATION IN RATS AT 2.0 T, Magnetic resonance in medicine, 37(6), 1997, pp. 969-972
Citations number
26
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Magnetic resonance in medicine → ACNP
ISSN journal
07403194
Volume
37
Issue
6
Year of publication
1997
Pages
969 - 972
Database
ISI
SICI code
0740-3194(1997)37:6<969:FMOMNI>2.0.ZU;2-5
Abstract
An animal model of sensory activation using fMRI at 2.0 T has been dev eloped, demonstrating that fMRI studies on animals need not be limited to high field magnets, These methods produced reliable image intensit y changes of 2% using median nerve stimulation in rats at 3 Hz and pro pofol as the anesthetic agent, At 6 Hz the activation was slightly but not statistically significantly greater, The feasibility of fMRI stud ies in animals using propofol suggests that it may be a useful anesthe tic for fMRI studies in agitated adult patients or in children.