Receptor-C-k controls cholesterogenesis and DNA replication in HEP G2 cells

The present study, addressed to understand the molecular link between LDL, cholesterogenesis and DNA replication in Hep G2 cell line, revealed that th e inhibitory effect of LDL upon cellular DNA synthesis, cholesterol synthes is and apo B-specific LDL-receptor gene expression at the transcriptional l evel, was mediated entirely through the activation of Receptor-C-k and not through its conventional apo B-specific LDL-receptor pathway. Based upon th ese experiments, we propose that Receptor-C-k controls the cellular cholest erogenesis as well as DNA replication and hence, it may have a crucial role in hepatic pathophysiological process.