Daily alcohol consumption and the risk of type 2 diabetes in Japanese men - The Osaka Health Survey

OBJECTIVE - To investigate the relationship between daily alcohol consumpti on and the risk of type 2 diabetes in a large Japanese cohort. RESEARCH DESIGN AND METHODS- We enrolled 6,362 Japanese men aged 35-61 year s who did not have diabetes,impaired fasting glucose, hypertension, or Live r cirrhosis at study entry Type 2 diabetes was defined as a fasting plasma glucose (FPG) level greater than or equal to 126 mg/dl or was diagnosed by a physician. Data on alcohol consumption were obtained from questionnaires. We confirmed 456 cases of type 2 diabetes during the 62,016 person-years o f follow-up. RESULTS - The relationship between daily alcohol consumption and the risk o f type 2 diabetes among lean men and among men with a higher BMI was parado xical. Among lean men (BMI less than or equal to 22.0 kg/m(2)), heavy drink ing was associated with an increased risk of type 2 diabetes. Men who consu med greater than or equal to 50.1 ml/day of alcohol had a relative risk (RR ) of 2.48 (95% CI 1.31-4.71) compared with nondrinkers after adjusting for age, BMI, regular physical exercise, parental history of diabetes, smoking habits, and FPG level. However, among men with a BMI greater than or equal to 22.1 kg/m(2), moderate drinking (29.1-50.0 ml/day) was associated with a decreased risk of type 2 diabetes. Daily moderate drinkers had a multiple adjusted RR of 0.58 (0.39-0.87) compared with nondrinkers. CONCLUSIONS - Among men with a BMI greater than or equal to 22.1 kg/m(2), m oderate alcohol consumption was associated with a reduced risk of type 2 di abetes, but among lean men (BMI less than or equal to 22.0 kg/m(2)), heavy alcohol consumption was associated with an increased risk of type 2 diabete s.