Structure of the human D1F15S1A locus: A chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein

Citation
Sjf. Degen et al., Structure of the human D1F15S1A locus: A chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein, DNA SEQ, 8(6), 1998, pp. 409-413
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
DNA SEQUENCE
ISSN journal
10425179 → ACNP
Volume
8
Issue
6
Year of publication
1998
Pages
409 - 413
Database
ISI
SICI code
1042-5179(1998)8:6<409:SOTHDL>2.0.ZU;2-B
Abstract
The human chromosome 3 locus coding for hepatocyte growth factor-like prote in/macrophage stimulating protein (HGFL/MSP) is homologous to two sets of a mplified loci on human chromosome 1 at 1p36. One copy of one of the amplifi ed loci (D1F15S1A) has been further characterized by restriction enzyme and DNA sequence analysis. A total of 8331 bp of continuous sequence was deter mined for this locus. The first 6878 bp of sequence is 96.1% identical to t he HGFL/MSP gene, while there is no homology between the two genes followin g nucleotide 6878. Based on the presence of a 5 bp deletion in putative exo n 2 and several downstream stop codons it is very likely that this gene is a pseudogene. Screening of a human liver cDNA library with a chromosome 1-s pecific probe indicates that at least several other members of the chromoso me 1 loci are transcribed.