Effect of fluvoxamine on the pharmacokinetics of quinidine

Objective: To investigate the possible involvement of cytochromes CYP1A2 an d CYP2C19 in the in vivo oxidative metabolism of quinidine. Methods: This was an open study of six healthy young male volunteers. The p harmacokinetics of a 200-mg single oral dose of quinidine were studied befo re and during daily treatment with 100 mg fluvoxamine. Biomarkers of other isozyme activities in the form of caffeine, sparteine, mephenytoin, tolbuta mide and cortisol metabolism were applied. Results: The results showed a statistically significant median reduction of 29-44% in the quinidine total apparent oral clearance, partial clearances by 3-hydroxylation and N-oxidation and residual clearance during fluvoxamin e treatment. Renal clearance was unaffected by fluvoxamine. Conclusions: The effect of fluvoxamine on the formation clearances of 3-hyd roxyquinidine and quinidine-N-oxide most likely reflects inhibition of cyto chrome P(450)3A4 by fluvoxamine at clinically relevant doses. The results o f this study do not rule out a possible involvement of CYP1A2 and CYP2C19 i n the in vivo oxidative metabolism of quinidine.