A case of inv(8)(pIIq24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16)

Authors
Chaffanet, M Mozziconacci, MJ Fernandez, F Sainty, D Lafage-Pochitaloff, M Birnbaum, D Pebusque, MJ
Citation
M. Chaffanet et al., A case of inv(8)(pIIq24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16), GENE CHROM, 26(2), 1999, pp. 161-165
Citations number
27
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
GENES CHROMOSOMES & CANCER
ISSN journal
10452257 → ACNP
Volume
26
Issue
2
Year of publication
1999
Pages
161 - 165
Database
ISI
SICI code
1045-2257(199910)26:2<161:ACOIAW>2.0.ZU;2-J
Abstract
We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southe rn blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The t ranslocation targets the MOZ gene from the 8p11 and the CBP gene from the 1 6p13 chromosomal regions. The breakpoints occur in the MOZ region encoding the acidic domain and in the 5' end of the CBP gene. These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias. Genes Chromosomes Cancer 26:161-165, 1999. (C) 1999 Wiley -Liss, Inc.