A procedure for the preparation of GM3 ganglioside from GM1-lactone

Authors
Mauri, L Casellato, R Kirschner, G Sonnino, S
Citation
L. Mauri et al., A procedure for the preparation of GM3 ganglioside from GM1-lactone, GLYCOCON J, 16(3), 1999, pp. 197-203
Citations number
31
Categorie Soggetti
Biochemistry & Biophysics
Journal title
GLYCOCONJUGATE JOURNAL
ISSN journal
02820080 → ACNP
Volume
16
Issue
3
Year of publication
1999
Pages
197 - 203
Database
ISI
SICI code
0282-0080(199903)16:3<197:APFTPO>2.0.ZU;2-O
Abstract
A simple procedure is described for preparing GM3 ganglioside, from a few m illigrams to grams, from GM1-lactone (Sonnino et al., (1985) Glycoconjugate J 2: 343-54) [1]. The synthesis was carried out under the following optima l conditions: 30 mM GM1-lactone in 0.25 M H2SO4 in DMSO, 30 min, 70 degrees C, nitrogen atmosphere, strong stirring. The yield of GM3 was 55%. The pro cedure applied to milligram amounts of GD1b-dilactone gave GD3 ganglioside.