Effect of an alpha(2) agonist (mivazerol) on limiting myocardial ischaemiain stable angina

A specific a, agonist, mivazerol, known to be effective in reducing myocard ial ischaemia when given intravenously immediately before an exercise toler ance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patient s with stable angina. A non-significant trend to reduction in electrocardio graphic signs of ischaemia was also noted. The clinical relevance of this i mprovement now needs to be tested in larger numbers.