Chiral separation of carboxymethyl derivatives of amines by liquid chromatography on reversed-phase silica gel coated with N-n-dodecyl-L-hydroxyproline

Authors
Yamazaki, S Ban'i, K Tanimura, T
Citation
S. Yamazaki et al., Chiral separation of carboxymethyl derivatives of amines by liquid chromatography on reversed-phase silica gel coated with N-n-dodecyl-L-hydroxyproline, HRC-J HIGH, 22(9), 1999, pp. 487-489
Citations number
16
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
ISSN journal
09356304 → ACNP
Volume
22
Issue
9
Year of publication
1999
Pages
487 - 489
Database
ISI
SICI code
0935-6304(199909)22:9<487:CSOCDO>2.0.ZU;2-I
Abstract
Carboxymethyl derivatives of amines containing a chiral a-carbon were separ ated into enantiomers by high-performance liquid chromatography using octad ecylsilanized silica gel coated with N-n-dodecyl-L-hydroxyproline as the st ationary phase and an aqueous solution containing copper(II) as the mobile phase. Detection was by post-column reaction involving derivatization to te rtiary amine and chemiluminescence reaction of ruthenium bipyridine complex .