Epstein-Barr virus genomes are found predominantly in IgA-positive B cellsin the blood of healthy carriers

Authors
Ehlin-Henriksson, B Zou, JZ Klein, G Ernberg, I
Citation
B. Ehlin-henriksson et al., Epstein-Barr virus genomes are found predominantly in IgA-positive B cellsin the blood of healthy carriers, INT J CANC, 83(1), 1999, pp. 50-54
Citations number
25
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF CANCER
ISSN journal
00207136 → ACNP
Volume
83
Issue
1
Year of publication
1999
Pages
50 - 54
Database
ISI
SICI code
0020-7136(19990924)83:1<50:EVGAFP>2.0.ZU;2-E
Abstract
B lymphocytes have been identified as the main reservoir of latent Epstein- Barr virus (EBV) in healthy virus carriers. We have established a semi-quan titative PCR method to estimate the EBV genome load in the blood B-cell sub population in healthy individuals. EBV DNA was detected in subfractionated IgM-, IgG- and IgA-positive B cells. Between 80% and 90% of the viral DNA w as found in the IgA-positive compared with the Iga-negative fraction. (C) 1 999 Wiley-Liss, Inc.