Jpa. Ioannidis et al., Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi, INT J EPID, 28(4), 1999, pp. 769-775
Citations number
25
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Background Large simple trials which aim to study therapeutic interventions
and epidemiological associations of human immunodeficiency virus (HIV) inf
ection, including perinatal transmission, in Africa may have substantial ra
tes of loss to follow-up. A better understanding of the characteristics and
the impact of women and children lost to follow-up is needed.
Methods We studied predictors and the impact of losses to follow-up of infa
nts born in a large cohort of delivering women in urban Malawi. The cohort
was established as part of a trial of vaginal cleansing with chlorhexidine
during delivery to prevent mother-to-infant transmission of HIV.
Results The HIV infection status could not be determined for 797 (36.9%) of
2156 infants born to HIV-infected mothers; 144 (6.7%) with missing status
because of various sample problems and 653 (30.3%) because they never retur
ned to the clinic. Notably, the observed rates of perinatal transmission we
re significantly lower in infants who returned later for determination of t
heir infection status (odds ratio = 0.94 per month, P = 0.03), even though
these infants must have had an additional risk of infection from breastfeed
ing. In multivariate models, infants of lower birthweight (P = 0.003) and,
marginally, singletons (P = 0.09) were less likely to return for follow-up.
The parents of infants lost to follow-up tended to be less educated (P < 0
.001) and more likely to be in farming occupations, although one educated g
roup, teachers and students, were also significantly less likely to return.
Of these variables, infant birthweight, twins versus singletons, and mater
nal education were also associated with significant variation in the observ
ed risk of perinatal transmission among infants of known HIV status.
Conclusions Several predictors of loss to follow-up were identified in this
large HIV perinatal cohort. Losses to follow-up can impact the observed tr
ansmission rate and the risk associations in different studies.