Pediatric medulloblastoma: Results of the Swiss Pediatric Oncology Group

Purpose In order to assess the potential correlation between clinical featu res and outcome 86 patients treated in Switzerland between 1972 and 1991 we re retrospectively evaluated. Patients and Methods There were 66 males and 20 females with a median age at diagnosis of 8.2 years. All patients comple ted surgery and craniospinal axis irradiation, 62 patients with and 24 pati ents without additional chemotherapy. Resection was complete in 30 patients , subtotal in 42, and in 14 cases only a biopsy or partial resection was po ssible. Patients were staged following the Chang staging system (Chang et a l. (1969). Radiology, 93, 1351-1359). T-stage: 24 T-2, 46 T-3, 13 T-4, and 3 T-x. M-stage: 39 M-0, 13 M-1, 17 M-2, 2 M-3, and 15 M-x. The following fe atures were analyzed for correlation with survival: sex, age, performance s tatus,T-stage, M-stage, resection, radiotherapy technical factors, and chem otherapy. Results M-stage at diagnosis and gender were the only clinical fe atures independently correlated with survival.