The operating diagram of a bioreactor is an illustrative way to present the
effect that the operating conditions have on its long-term behavior. It ca
n be constructed if a mathematical model of the bioreactor is available. Th
e procedure for constructing the operating diagram consists in analyzing th
e dynamic behavior of the system of the differential equations of the model
. Some methods are described that can be used in computing operating diagra
ms of bioreactors. They are based on numerical bifurcation techniques for s
ystems of differential equations. Both cases of bioreactors with constant a
nd periodically varying operating conditions are considered. (C) 1999 Elsev
ier Science B.V. All rights reserved.