Comparison of two implantation sites for testing intraosseous biocompatibility

The purpose of this study was to compare two implantation sites-the mandibl e and the femur of the rabbit-for testing in vivo intraosseous bio-compatil ity, Twenty-two new Zealand rabbits were anesthetized, and the mandibular a nd femur bones were exposed. A hybrid glass ionomer cement or zinc oxide eu genol cement was loaded into silicone carriers and inserted into the two bo nes after drilling the two cortical plates. Eleven rabbits were killed 4 wk after implantation, and 11 rabbits were killed after 12 wk, The mandibles and femurs were prepared using standard histological procedures; tissue rea ctions were graded from none to severe. At 4 wk, no statistically significa nt difference was found between the two implantation sites. After 12 weeks, bone healing was statistically better in the mandible than in the femur. T he mandible seems to be a better implantation site in the case of intraosse ous implantation tests. The intraosseous biocompatibility of Vitremer was s imilar at 4 wk and superior at 12 wk to that of Super-EBA.