TOLERABILITY OF NABUMETONE - A PILOT IN-VITRO STUDY SHOWING ABSENCE OF INJURY TO ARTICULAR-CARTILAGE

Nabumetone, a compound of the naphthylalkanone class, has shown consid erable anti-inflammatory, analgesic and antipyretic effects, together with high systemic and organ-specific tolerability. Its reputation for tolerability has been increased by an in-vitro study evaluating the m ature collagen metabolism's markers under nabumetone treatment. which shows that, nabumetone does not interfere with collagen synthesis. The refore, unlike some nonsteroidal anti-inflammatory drugs, nabumetone m ight not be injurious to articular cartilage. This feature makes nabum etone even safer for long-term treatment of rheumatic and orthopaedic conditions.